Table 4.
Geometric Mean and 95% CI of Velsecorat versus Placebo 0- to 24-hr Plasma Cortisol Ratios After Single (Day 1) and Repeated, Once-Daily Dosing for 12 Days (Day 16)
| Study/ Day | Parameter | Treatment | n | Geometric LS Mean | Pairwise Comparison to Placebo | |
|---|---|---|---|---|---|---|
| Ratio (%) | 95% CI | |||||
| Single dose part | ||||||
| Day 1 | Post dose/baseline ratio for AUEC(0–24) | Placebo | 12 | 1.071 | ||
| 7 ug | 6 | 1.041 | 97.18 | (88.41, 106.82) | ||
| 38 µg | 6 | 1.074 | 100.27 | (91.03, 110.45) | ||
| 187 µg | 6 | 0.9745 | 91.01 | (82.54, 100.36) | ||
| 624 µg | 5 | 1.035 | 96.66 | (87.52, 106.74) | ||
| 1248 µg | 6 | 0.9721 | 90.79 | (82.50, 99.90) | ||
| 1872 µg | 6 | 0.9238 | 86.28 | (78.23, 95.15) | ||
| Multiple dose part | ||||||
| Day 16 | Postdose/baseline ratio for AUEC(0–24) | Placebo | 8 | 0.9011 | ||
| 312 ug | 5 | 0.8562 | 95.01 | (77.93, 115.84) | ||
| 1248 ug | 5 | 0.7830 | 86.89 | (71.45, 105.67) | ||
| 1872 ug | 5 | 0.6976 | 77.42 | (63.66, 94.15) | ||