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. 2022 Mar 3;15:1617–1635. doi: 10.2147/JIR.S332793

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© 2022 Jaggers et al.

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Stress and antibiotics have orthogonal effects on the colonic and ileal microbiomes. (A) Abx reduce Shannon Diversity Index in the colon (main effect of Abx, p < 0.0001). (B) Principle Coordinate Plot of Bray-Curtis distances in the colon. Colonic Bray-Curtis distances were affected by stress (main effect of Str, p < 0.005) and by antibiotics (main effect of Abx, p < 0.001). (C) Relative abundances of specific taxa found to be increased by Stress in the colon (main effects of Stress, p < 0.05). (D) Shannon Diversity Index in the ileum was not affected in Abx or Str mice. (E) Principle Coordinate Plot of Bray-Curtis distances in the ileum. Ileal Bray-Curtis distances were affected by stress (main effect of Str, p < 0.05) and by antibiotics (main effect of Abx, p < 0.001). (F) Relative abundances of specific taxa found to be affected by stress in the ileum (main effects of Stress, p < 0.05). n = 9 per group from 3 replicate experiments.