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. 2022 Mar 3;15:1617–1635. doi: 10.2147/JIR.S332793

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© 2022 Jaggers et al.

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Stress effects on serum LBP and cytokine levels are mediated by an intact microbiome. LBP and cytokine levels were assessed in the serum after behavioral testing. Mice exposed to stress had significant increases in (A) LBP, (B) IL-6, (C) IL-1β, (D) TNF-α, and (E) IL-10 (all main effects of Stress). In addition, Antibiotics reduced (A) LBP, (B) IL-6, and (C) IL-1β (main effects of Abx). (F) In Veh and Abx-treated mice that were exposed to Stress or Ctrl conditions, LBP levels in the serum were inversely related to the percentage of spontaneous alternations on the Y maze (r = −.35, p < 0.05). n = 9–11 mice per group. Data are from 3 replicate experiments.