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. 2022 Mar 3;15:1617–1635. doi: 10.2147/JIR.S332793

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© 2022 Jaggers et al.

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Stress effects on colonic mucus and antimicrobial peptides, as well as serum LBP and IL-6, but not TNF-α and IL-10, are CD14-dependent. (A) Representative FISH staining of total bacteria (EUB-338-Cy3), lectin-based fluorescence staining for terminal fucose on mucin (UEA1-flouorescein; fucose), and host nuclei staining (DAPI) in the colon of Stress and Ctrl CD14^−/− mice. (B) quantification of mucus thickness showed that stress does not affect mucus thickness in CD14^−/− mice., (C) Colonic Reg3b and (D) Reg3g gene expression was unaffected by Stress in CD14^−/− mice. CD14^−/− exposed to stress did not have increases in serum (E) LBP or (F) IL-6, or (G) IL-1β but still showed increases in (H) TNF-α and (I) IL-10 (*p < 0.05 Stress vs Ctrl). n = 6–9 per group from 3 replicate experiments.