Table 2.

Comparison of MoCA scores, serum thiamin, folic acid and homocysteine in the control and treatment group at baseline, 48 weeks and 96 weeks of follow-up.

	Treatment group (n = 22)	Control group (n = 16)	p Value
MoCA
Baseline	21.95 ± 3.81	20.69 ± 3.40	0.297
48 weeks	25.68 ± 2.40	20.00 ± 3.95	<0.001
96 weeks	25.68 ± 1.96	19.63 ± 3.58	<0.001
Comparison between 96 weeks and baseline, p value	<0.001	0.657
Treatment difference over time, p value	<0.001	0.304
Thiamin (nmol/L)
Baseline	53.63 ± 7.33	51.98 ± 10.13	0.563
48 weeks	57.79 ± 6.09	54.90 ± 6.28	0.163
96 weeks	57.60 ± 5.86	52.87 ± 4.45	0.011
Comparison between 96 weeks and baseline, p value	0.168	1.000
Treatment difference over time, p value	0.063	0.499
Folic acid (ng/mL)
Baseline	7.88 ± 2.18	8.39 ± 2.63	0.519
48 weeks	21.94 ± 4.85	8.09 ± 4.62	<0.001
96 weeks	18.35 ± 7.94	7.3 ± 4.83	<0.001
Comparison between 96 weeks and baseline, p value	<0.001	0.870
Treatment difference over time, p value	<0.001	0.719
Homocysteine (μmol/L)
Baseline	43.55 ± 21.81	48.72 ± 27.43	0.522
48 weeks	33.64 ± 13.04	41.36 ± 13.34	0.083
96 weeks	32.58 ± 13.42	45.69 ± 18.54	0.016
Comparison between 96 weeks and baseline, p value	0.111	1.000
Treatment difference over time, p value	0.063	0.594

Notes: The normal range for blood thiamin concentration is approximately 70–180 nmol/L [18] and the normal range for serum levels of folate acid is approximately 2.7–17 ng/ml [19] in the general population.