2.
67个共同靶标的GO和KEGG通路富集分析
Go and KEGG pathway enrichment analysis of 67 common targets
| Biological Process | Targets | Signaling pathways |
| AKT1, CCL2, CTNNB1, ICAM1, IFNG, IL1P, KDR, MAPK14, MMP2, MMP9, NOS3, PECAM1, SELE, TNF, TNFRSF1A, TP53, VCAM1, VEGFA | Fluid shear stress and atherosclerosis(KEGG: 05418) | |
| Angiogenesis | AKT1, KDR, MAPK14, NOS3, PTGS2, VEGFA | VEGF signaling pathway(KEGG: 04370) |
| AKT1, FGFR1, IGF1, IL6, JAK2, KDR, NOS3, RXRA, TLR2, TLR4, TP53, VEGFA | PI3K-Akt signaling pathway(KEGG: 04151) | |
| Oxidative stress | AKT1，IGF1，IL10，IL6，MAPK14，SIRT1，TGFP1，TGFPR2 | FoxO signaling pathway(KEGG: 04068) |
| AKT1，CASP3，FAS，FGFR1，HSPA8，IGF1，IL1P，KDR，MAPK14, TGFP1，TGF^R2, TNF，TNFRSF1A，TP53, VEGFA | MAPK signaling pathway(KEGG: 04010) | |
| CD40, ICAM1，IL1P，PTGS2, TLR4, TNF，TNFRSF1A，VCAM1 | NF-kappa B signaling pathway(KEGG: 04064) | |
| Energy metabolism | AKT1，CD36, HMGCR，IGF1，PPARG，SIRT1 | AMPK signaling pathway(KEGG: 04152) |
| AKT1，HIF1A，IFNG，IGF1，IL6，NOS3，TIMP1，TLR4，VEGFA | HIF-1 signaling pathway(KEGG: 04066) | |
| AKT1，CASP3, CCL2, FAS，ICAM1，IL1^，IL6, MAPK14，MMP3, MMP9, PTGS2, SELE，TNF，TNFRSF1A，VCAM1 | TNF signaling pathway(KEGG: 04668) | |
| Inflammatory response | AKT1，CD40, IL1P，IL6, MAPK14, TLR2, TLR4, TNF | Toll-like receptor signaling pathway(KEGG: 04620) |
| CASP3，CCL2，IFNG，IL1P，IL6，MAPK14，MMP3，MMP9，PTGS2，TNF | IL-17 signaling pathway(KEGG: 04657) |