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. 2022 Feb 22;13:805451. doi: 10.3389/fimmu.2022.805451

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Copyright © 2022 Gao, Cao, Deng, Yang, Song, Ni, Xie, Fan, Ou, Huang, Lin, Liu, Li, Sun, Cheng, Wu, Xia, Deng, Mou and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characteristics of tissue-restricted antigen expression during mTEC development. (A) UMAP visualization of the expression of Aire, Aire-dep TRAs, Aire-enh TRAs, and Aire-ind TRAs in E15.5, newborn, and 5-week thymus. Each point corresponded to a single cell, and each color represented a cell cluster (first panel). Color represented maximum-normalized mean expression of Aire and TRAs (2–4 panels). (B) Average TRAs expression in each cell cluster in E13.5, E14.5, E15.5, E16.5, newborn, and 5-week thymus (upper panel, Aire-dep TRAs; middle panel, Aire-enh TRAs; lower panel, Aire-ind TRAs). (C) Average TRAs expression in Aire⁺ cells in E14.5, E15.5, E16.5, newborn, and 5-week thymus. Aire⁺ cells were selected as ≧ 2 UMI counts in a single cell. (D) Heat map showing differently expressed genes in C1 (cluster 1), C4, and C5 cells from 5-week thymus. (E, F) Violin plots showing the smoothened expression distribution of selected genes in C1, C4, and C5 cells from 5-week thymus.