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. 2022 Feb 22;13:805451. doi: 10.3389/fimmu.2022.805451

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Copyright © 2022 Gao, Cao, Deng, Yang, Song, Ni, Xie, Fan, Ou, Huang, Lin, Liu, Li, Sun, Cheng, Wu, Xia, Deng, Mou and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The dynamic heterogeneity of thymic endothelial cells across development. (A) UMAP visualization of the thymic endothelial cells colored by cell type, left panel and by sample origin, right panel (sample origin: fetal including E11.5, E12.5, E13.5, E14.5, E15.5, and E16.5; postnatal including newborn and 5-week thymus). (B. C) UMAP visualization of the expression of curated feature genes specific for 4 EC subtypes. (D) UMAP visualization of the expression of Ly6C, Selp, and Lrg1 in E14.5, newborn, and 5-week samples. (E–H) Average expression (normalized counts) of selected genes in E11.5, E13.5, E15.5, newborn, and 5-week thymic ECs.