Table 1.

Participant characteristics by aMCI status (n = 67)

Variable	aMCI − (n = 49)	aMCI + (n = 18)	p value	Effect size
Descriptive demographics
Age, mean (SD)	57.7 (6.7)	57.8 (4.9)	.97	g = .02
Education, mean (SD)	14.2 (2.7)	15.1 (2.4)	.20	g = .34
Male, n (%)	41 (84%)	16 (89%)	.59	OR = 1.56
Non-Hispanic white, n (%)	37 (76%)	16 (89%)	.39	OR = 2.59
Medical comorbidities and anthropometric measurement
Hyperlipidemia, n (%)	26 (57%)	11 (61%)	.74	OR = 1.21
Ever smoker, n (%)	18 (39%)	7 (39%)	.99	OR = 0.99
Hypertension, n (%)	18 (39%)	8 (44%)	.70	OR = 1.24
Current smoker, n (%)	16 (35%)	6 (33%)	.91	OR = 0.94
Diabetes, n (%)	13 (28%)	4 (22%)	.62	OR = 0.73
Hepatitis C virus, n (%)	9 (20%)	5 (28%)	.48	OR = 1.58
Body mass index, mean (SD) a	26.3 (5.2)	28.5 (6.3)	.15	g = .39
Pulse pressure	58.8 (18.3)	58.3 (19.4)	.92
Current medications
Lipid-lowering drug, n (%)	18 (37%)	8 (44%)	.57	OR = 1.38
NSAID, n (%)	15 (31%)	5 (28%)	.82	OR = 0.87
Antihypertensive, n (%)	12 (24%)	8 (44%)	.12	OR = 2.47
Antidepressant, n (%)	15 (31%)	11 (61%)	.02	OR = 3.56
Psychiatric characteristics/diagnoses
BDI-II total, median [IQR]	8.0 [2.0, 16.0]	8.5 [1.8, 15.8]	.97
Current MDD, n (%)a	5 (10%)	3 (17%)	.50	OR = 1.72
LT MDD, n (%)b	27 (55%)	11 (61%)	.66	OR = 1.28
LT alcohol use disorder, n (%)b	23 (47%)	8 (44%)	.86	OR = 0.90
LT cannabis use disorder, n (%)b	13 (27%)	5 (28%)	.92	OR = 1.07
LT meth use disorder, n (%)b	4 (22%)	15 (31%)	.49	OR = 0.65
HIV disease characteristics
Est. duration of HIV disease, (years) median [IQR]a	20 [11.9, 25.1]	16.2 [10.9, 25.3]	.82
AIDS, n (%)b	32 (65%)	11 (61%)	.75	OR = 0.83
Current CD4, median [IQR]	597 [363, 775]	663 [566, 1,049]	.11
Nadir CD4, median [IQR]a	165 [21, 300]	140 [42, 303]	.75

BDI-II Beck Depression Inventory-II, LT lifetime, MDD major depressive disorder, NSAID nonsteroidal anti-inflammatory drug