Table 4.
Germline Immune Genetic Associations with Oncologic Surgery Outcomes
| Ref | Cancer | Treatment | Outcome | # subjects | Immune Genes | Immune gene function* | Main germline immune genetic associations found | Statistical significance of association |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| (70) | Colorectal | Surgery | RFS, OS | 668 | CCL2, PDCD1 | Cytokine – Chemokine/Antimicrobial (CCL2); T cell receptor signaling and antimicrobial (PDCD1) | CCL2 rs4586 TT genotype was strongly correlated with reduced OS. PDCD1 rs10204525 AA genotype was associated with shorter RFS and OS. |
CCL2: OS, HR=1.72 (1.14–2.61), p=0.010; PDCD1: OS, HR=1.48 (1.05–2.07), p=0.024; PDCD1: RFS, HR=1.66 (1.15–2.41), p=0.007 |
| (71) | Prostate | Surgery | Recurrence | 484 | IL10, CRP, IL1B, | Cytokine – Interleukin; Antimicrobial | SNPs in IL10, CRP and IL1B were associated with risk of recurrence independent of pathologic prognostic factors. | IL10 rs1800872 A allele: OR = 1.76 (1.00–3.10); IL10 rs1800896 G allele: OR=0.66 (0.48–0.91); CRP: OR= 0.65 (0.49–0.86); IL1B: OR=0.80 (0.60–1.06) |
| (72) | Lung NSCLC | Surgical resection | OS, RFS, metastasis | 385 | IL10 | Cytokine - Interleukin | Patients with IL10 non-ATA haplotypes had reduced OS and RFS. | OS: HR=1.43 (1.10–1.86), p=0.007; RFS: HR=1.56 (1.20–2.02), p<0.001 |
| (73) | Melanoma | Radiation, surgery, dacarbazine | Melanoma specific survival (MSS) | 241 | PDCD1 | T cell receptor signaling and antimicrobial | Poorer MSS was associated with the PD1.5 CC genotype. | HR=2.62 (1.16–5.92), p=0.02 |
| (74) | Lung NSCLC | Surgery | Survival time | 828 | CCL8 | Cytokine – Chemokine / antimicrobial | CCL8 rs3138035 was associated with improved survival time after surgery. | HR=0.47 (0.31–0.71) |
*
Immune gene function: The immune system role of the protein encoded by the gene identified as being associated with cancer treatment outcome is indicated. The category designation was made as per Immport.org/shared/genelists and/or Genecards.org. Note that Cytokines can have various functions in mediating the immune system (such as inflammation, response to infection, etc.) through cell signaling; please refer to Genecards.org for a more comprehensive discussion of the gene function.