Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 7;12:4028. doi: 10.1038/s41598-022-08051-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Expression of elements related to programmed cell death in cancer cells treated with thiol drugs. (a) Western blot analysis of the expression of ERK 1/2 and its phosphorylated form. Graphs depict the decrease of ERK 1/2 and its phosphorylated form under treatment with rabeprazole (red bars) and auranofin (orange bars). (b) Western blot analysis of the expression of Bcl-2 and Bax. Graphs depict the expression of these two elements under treatment with rabeprazole (red bars) and auranofin (orange bars). (c) Western blot analysis of the expression of pro caspase-7 and the apparition of its cleaved form. Graphs depict the relative quantities of these two forms of Casp-7 under treatment with rabeprazole (red bars) and auranofin (orange bars). β-Actin was used as a charge control. Differences among groups were assessed with one-way ANOVA and Tukey’s test with p value = 0.001 ***. (d) TUNEL assays of cancer cells do not treated (Control) or treated with 700 μM rabeprazole (+ Rabeprazole) or 70 μM auranofin (+ Auranofin). DAPI was used for nuclei staining. Photographs are at ×40. Full-length blots of (a–c) panels are shown in Suppl. Fig. S5.