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. 2022 Mar 7;12:4016. doi: 10.1038/s41598-022-08064-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental setup and clinical outcomes. (A) Cartoon summarizing the experimental setup and treatment groups in the ALS mouse model (n = 6 each group). The timing and duration of immunomodulatory drug applications are shown in green and GRPs transplantation in red. All animals received GRPs except Injury group, which received a sham transplantation. (B) Kaplan–Meier curves indicating survival by group. sPIF transplantation seems superior but did not reach statistical significance. (C) Functional assessments using hanging wire test by group. sPIF treatment resulted in significant improvement of motor outcome. mGRPs: glial-restricted precursors; sPIF: synthetic PreImplantation Factor; Tac: Tacrolimus, CB: co-stimulatory blockade. Differences between groups were analyzed using a repeated measure ANOVA model or using a log-rank test.