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. 2022 Mar 7;12:4016. doi: 10.1038/s41598-022-08064-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Neuronal survival. (A) Representative images of mature neurons cells (NeuN positive cells) in two regions of the brain. (B) All therapeutic groups reduced the number of microglial cells significantly. mGRPs: glial-restricted precursors; sPIF: synthetic PreImplantation Factor; Tac: Tacrolimus, CB: co-stimulatory blockade. *p < 0.05; **p < 0.01; ***p < 0.001. Differences are calculated using one-way analysis of variance (ANOVA) followed by a post-hoc test (Bonferroni test).