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. 2022 Mar 7;12:3687. doi: 10.1038/s41598-022-07642-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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UCHL5 is required for the functional activity of Axin1. UCHL5 blocks ubiquitination of Axin1 DIX domain. As a result, Axin1 is stabilized and successfully polymerized. However, absence of UCHL5 promotes DIX ubiquitination and results in failure of Axin1 polymerization and stabilization. The image was generated using Microsoft PowerPoint software Version 1907 (Build 11901.20176).