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. 2021 Sep 29;29(3):585–599. doi: 10.1038/s41418-021-00876-y

Fig. 2. Foxo3a controls the immune cell numbers in the colonic lamina propria.

Fig. 2

a, b Representative FACS plots showing the gating strategy for myeloid cells in the colon lamina propria of the four groups of mice. c Total numbers of myeloid subsets in the colon lamina propria of the four groups of mice. d–f Representative FACS plot showing the viability of various myeloid cell subsets in the colon lamina propria in the four groups of mice. g, h Representative FACS plots showing the expression of CD4 and Foxp3 in the colonic lamina propria of the four groups of mice. i Total numbers of lymphoid subsets in the colonic lamina propria of the four groups of mice. j Survival of Foxo3a−/−IL10−/− mice depleted of myeloid cells or T cells using appropriate antibodies (mentioned in the methods section) given twice a week (200 μg/injection) from day 30 till day 100 of birth. The Mantel–Cox test was used for survival analysis. All graphs depict mean ± SEM. Statistics were done using One-way ANOVA (*P < 0.05, ***P < 0.001, and ****P < 0.0001).