Figure 1. Traditional and recent CAR T cell designs. (A) Traditional single antigen-binding CAR designs face antigen escape within haematological and solid tumors which can be alleviated by (B) dual-targeting CAR T cells. Top; Bispecific (Tandem) CAR T cells. Bottom; CAR T cells secreting BiTEs that target a different TAA. (C) universal CARs and their adapters.