TABLE 2.

Pharmacokinetic parameters in children^a and in rats used to determine infusion rates for simulation studies with rats

Species, pharmaco-kinetic model	Parameter	Amoxicillin	Clavulanate
Human, C(t) = A(exp−ket −exp−kat)	A (μg/ml)	22	4.5
	kel (H−1)	0.56	0.61
	Ka (h−1)	1.56	1.57
Rat, C = a · exp−λtb	a (μg/ml)	240	27
	λ (h−1)	2.1	2.4
	Dose (mg/kg)	44	24

^aData for children have been published previously (13). 

^bC is concentration, a is the zero-time intercept, and λ is the elimination rate constant.