Fig. 1. Estrogen receptor β (ERβ, gene: ESR2) is highly expressed in DLBCL.
A Normalized ERβ mRNA expression levels for DLBCL cases and normal B-cell subsets (germinal center B cells, naive B cells, and memory B cells) obtained from a public repository (GSE12195). B ERβ RNA sequence expression data for DLBCL, normal B cells, acute myeloid leukemia (AML), normal leukocytes, breast cancer (BC), and normal breast tissue. C ERβ Nanostring counts for Burkitt lymphoma (BL), Hodgkin’s lymphoma (HL), DLBCL, follicular lymphoma (FL), mantle cell lymphoma (MCL), multiple myeloma (MM), T-cell lymphoma (T cell), AML, lymphoblastoïd cell lines (LCL), and BC cell lines. D ERα and ERβ Nanostring counts for DLBCL cell lines and MCF7. E Western blot of ERβ and ERα protein expression in DLBCL cell lines and the BC cell line MCF7. F Immunohistochemical staining for ERβ in normal breast and DLBCL patient tissue. G left fusion 18F-FDG PET/CT transaxial slide, right 18F-FDG PET Maximum Intensity Projection. H Left fusion 18F-FES PET/CT transaxial slide, right 18F-FES PET Maximum Intensity Projection.