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. 2022 Mar 7;12(3):36. doi: 10.1038/s41408-022-00631-7

Fig. 3. Tamoxifen induces apoptosis in DLBCL.

Fig. 3

A Annexin V/PI flow cytometry staining for apoptosis after 24 h tamoxifen treatment in SC1 cell line. B Western blot for PARP1/cleaved PARP1 and active caspase-3 after 24 h of tamoxifen treatment in OCILY3 cell line. C Rescue experiment for tamoxifen in OCILY3 cell line with caspase inhibitor QVD after 48 h treatment. Data were normalized to controls and are shown for three independent replicates. D Combination treatment of tamoxifen with CHOP chemotherapy for 72 h in four DLBCL cell lines. Data were normalized to controls and are shown for three independent replicates. E Combination index (CI) for the combination treatment of tamoxifen with CHOP chemotherapy for 72 h in four DLBCL cell lines. CI was calculated using CompuSyn software.