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. 2022 Mar 7;12:3678. doi: 10.1038/s41598-022-07313-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ASAP3-R3 performance in cardiomyocytes. (a) Representative induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) expressing ASAP3 or ASAP3-R3. Epifluorescence images were acquired using Hamamatsu HCImage software and color channels assigned in NIH Fiji 2.1. (b) Representative single-trial ∆R/R or ∆F/F responses to spontaneous cardiac APs of cells expressing ASAP3, expressing ASAP3-R3, or expressing ASAP3-R3 and treated with isoproterenol (ISO). Graphs were generated in Microsoft Excel for Mac 16. (c) Characterization of traces obtained from ASAP3 (n = 6), ASAP3-R3 (n = 10), or ASAP3-R3 + ISO (n = 7). Graphing and statistical analyses were performed in GraphPad Prism 7.