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. 2022 Mar 7;13(3):212. doi: 10.1038/s41419-022-04660-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The schematic description shows the biological impact of PAM on human lung cancer cells. PAM-induced intracellular ROS triggers oxidative stress genes regulation, mitochondria dysfunction, and control of FSP1/NRF2 expression. Subsequently, upregulation of lipid ROS levels ultimately induce ferroptosis.