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. 2022 Mar 7;12:3612. doi: 10.1038/s41598-022-07317-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of endurance exercise on gut microbiota composition in ApoE knockout mice. The (a) α-diversity (observed and Chao1 index) and (b) β-diversity (unweighted and weighted UniFrac PcoA) in the WT CD, ApoE CD, ApoE WD, and ApoE WE EX groups are indicated by the same colors used in Fig. 2. The line inside the box represents the median, and the whiskers represent the lowest and highest values within the 1.5 interquartile range. Different superscript letters (a and b) indicate significant differences (P < 0.05) in one-way ANOVA.