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. 2022 Mar 7;13(3):216. doi: 10.1038/s41419-022-04661-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A, B Levels of the global N6-methyladenine (6mA) in DNA were assessed via ELISA in primary breast cancer tissues (BC), normal breast tissues (BN), and adjacent non-breast cancerous tissues (NBC). Unpaired and paired t-tests were performed in (A) and (B), respectively. C Statistical analysis (Student’s t-test) of N6AMT1 and ALKBH1 protein between BC (n = 96) and NC (n = 14). D IHC staining for N6AMT1 in BC and BN samples. E Correlation between N6AMT1 protein and DNA 6mA levels in BC tissue was analyzed by Spearman’s t-test. F Kaplan–Meier survival curves of the disease-free survival (DFS) based on N6AMT1 expression level. G Box plots showing N6AMT1 mRNA expression from the ONCOMINE database analysis of breast statistics. *P < 0.05 vs. normal breast tissues. H, I Prognostic value of N6AMT1 mRNA levels in BC patients from the studies of Tumor Breast (MDC) Bertucci and (Taxane–Anthracycline) Booser. Statistical analysis was done using the log-rank test.