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. 2022 Mar 7;13(3):216. doi: 10.1038/s41419-022-04661-8

Fig. 3. Silencing N6AMT1 reduces DNA 6mA and promotes the growth of BC cells in vivo.

Fig. 3

A Western blot showing N6AMT1 was successfully knocked down by shN6AMT1 lentivirus in MDA-MB-453 cells. The value is the relative ratio to sh-NC. Bold fonts indicate p-values less than 0.05, calculated by Student’s t-test. B Reduction of 6mA in MDA-MB-453 cells following N6AMT1 knockdown, as determined by ELISA. C–E Tumor growth curves (C), representative xenografts (D), and tumor weights (E) show that N6AMT1 knockdown enhances MDA-MB-453 cell xenograft growth. F Representative immunostaining for N6AMT1, RB1, TP53, and Ki67 in xenografts of sh-N6AMT1 and sh-Control tumors.