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. 2022 Mar 7;11:7. doi: 10.1186/s13619-021-00102-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Transcriptome profiling of brain organoids exposed to breast cancer cell-derived exosomes. A Hierarchical clustering of unregulated DEGs in brain organoids treated with exosomes (the exosomes group) compared with the organoids without exosomes treatment (the control group). B Go enrichment of upregulated DEGs associated with molecular function in exosomes groups. C Go enrichment of upregulated DEGs associated with biological process in exosomes groups. D Go enrichment of upregulated DEGs related to cellular component in exosomes groups. E KEGG pathways of upregulated DEG in brain organoids exposed to exosomes. The x-axis and y-axis represent the rich ratio and the KEGG terms, respectively. The color and size of the circle indicates adjusted P-value and gene number, respectively