Table 1.

Growth Data and Biomarkers of Study Subjects According to Their Genetic Risk

Variable	Low risk (n=108)	Moderate to high risk (n=111)	P value
Age, yr	8.9±0.4	8.8±0.3	0.05
Height SDS	0.67±0.82	0.75±0.92	0.52
Corrected height SDS	−0.04±0.84	0.22±0.93	0.03
Weight SDS	0.62 (0.16 to 1.24)	0.71 (0.08 to 1.5)	0.59
BMI SDS	0.31 (−0.28 to 1.17)	0.36 (−0.42 to 1.2)	0.95
Overweight, %	21.3	19.8	0.87
Obese, %	8.3	12.6	0.38
IGF-1, μg/L	157.2±43.7	153.7±40	0.54
IGFBP-3, μg/mL	4.09±0.81	4.26±0.77	0.12
IGF-1/IGFBP-3 molar ratio	0.211±0.039	0.199±0.035	0.03
Δ Height SDS	0.16±0.85 (n=101)	0.18±0.85 (n=101)	0.85
Δ BMI SDS	−0.29 (−0.98 to 0.60) (n=101)	−0.22 (−1.17 to 0.62) (n=101)	0.83

Values are expressed as mean±1 standard deviation or median (interquartile range).

SDS, standard deviation score; BMI, body mass index; IGF-1, insulin-like growth factor 1; IGFBP-3, insulin-like growth factor binding protein 3; Δ, change between the present age and 18 months of age.