Table 6.
Summary of randomized controlled trials comparing extended lymph node dissection (LND) and standard LND
| Author | Comparison group | Number | Morbidity rate (%)a) | p-value | Postoperative mortality rate (%) | p-value | Survival rate (%) | p-value |
|---|---|---|---|---|---|---|---|---|
| Farnell et al. (2005) [41] | Extended Standard |
39 40 |
N/A | NSa) | 1 (2.6) 0 (0) |
NS | 17 (5-yr) 16 (5-yr) |
0.320 |
| Nimura et al. (2012) [42] | Extended Standard |
50 51 |
22.0 19.6 |
NS | 1 (2.0) 0 (0) |
NS | 6.0 (5-yr) 15.7 (5-yr) |
0.119 |
| Jang et al. (2014) [43] | Extended Standard |
86 83 |
37 (43.0) 27 (32.5) |
0.160 | 2 (2.3) 0 (0) |
NS | 35.7 (2-yr) 44.5 (2-yr) |
0.122 |
| Jang et al. (2017) [44] | Extended Standard |
86 83 |
N/A | - | N/A | - | 14.4 (5-yr) 18.4 (5-yr) |
0.388 |
| Ignjatovic et al. (2017) [45] | Extended Standard |
30 30 |
1 (3.3)b) 0 (0) |
> 0.05 | 2 (6.7) 1 (3.3) |
> 0.05 | 7.1 (5-yr) 6.9 (5-yr) |
0.057 |
N/A, not available; NS, not significant.
a)Complications were evaluated separately and not as a whole. There were no differences for all sub-specified complications. b)Postoperative bleeding.