Table 9.
Summary of retrospective studies comparing artery first approach in pancreaticoduodenectomy (AFA-PD) and conventional pancreaticoduodenectomy (C-PD)
| Author | Comparison group | Number | Op time (min) | p-value | Blood loss (mL) | p-value | R0 rate (%) | p-value | LN harvest (n) | p-value | Morbidity (%) | p-value | Survival (%) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kurosaki et al. [121] | C-PD AFA-PD |
35 40 |
526 516 |
0.651 | 1,352 1,307 |
0.814 | 71.4 72.5 |
1.00 | N/A | 42.9 30.0 |
0.352 | 17.1a) 52.8 |
0.016 | |
| Aimoto et al. [70] | C-PD AFA-PD |
19 19 |
481 490 |
NS | 1,568 490 |
< 0.05 | 68 74 |
NS | 3.4 7.9 |
< 0.01 | 10 20 |
NS | 40b) 20 |
NS |
| Hirono et al. [119] | C-PDc) AFA-PD |
30 28 |
371 417 |
0.007 | 502 313 |
0.023 | 86.7 100 |
0.045 | 23.5 23 |
0.919 | 10 17.9 |
0.386 | N/A | 0.021 |
| C-PDd) AFA-PD |
28 30 |
452 459 |
0.210 | 920 508 |
0.003 | 85.7 80.0 |
0.565 | 26 26.5 |
0.668 | 17.9 13.3 |
0.634 | N/A | 0.260 | |
| Pędziwiatr et al. [122] | C-PD AFA-PD |
19 12 |
425 467 |
0.13 | 392 408 |
0.33 | 63.2 66.7 |
0.84 | 139. 19.3 |
0.03 | 63.2 66.7 |
0.84 | N/A | N/A |
| Wang et al. [120] | C-PD AFA-PD |
39 78 |
384 313 |
0.014 | 756 534 |
0.043 | 82.1 83.3 |
0.534 | N/A | 46.2 41.0 |
0.603 | N/A | N/A |
OP, operation; LN, lymph node; N/A, not available; NS, not significant.
a)Three-year survival rate; b)2-year survival rate; c)resectable pancreas cancer; d)borderline resectable cancer.