TABLE 2.
Incidence and level of virus titers in guinea pig vaginal swabs collected on day 2 p.i.
| Expt no. | Treatment group (dose [mg/kg/day]) | No. of animals/ group | No. positive for virus (%) | Mean virus titer (log10 PFU/ml)
|
|
|---|---|---|---|---|---|
| All animals | Positive animals | ||||
| 1 | P-4010 (40) | 10 | 10 (100.0) | 4.14 | 4.14 |
| ACV (20) | 9 (90.0) | 3.81 | 5.06 | ||
| Placebo | 10 (100.0) | 4.85 | 4.85 | ||
| 2 | P-4010 (40) | 15 | 11 (73.3) | 1.95 | 3.86 |
| PCV (20) | 14 (93.3) | 3.18 | 3.77 | ||
| Placebo | 14 (93.3) | 3.02 | 3.56 | ||
| PBS | 13 (86.7) | 2.29 | 3.13 | ||
| 4 | P-4010 (40) | 16 | 16 (100.0) | 3.25 | 3.25 |
| P-4010 (30) | 13 (81.3) | 2.39 | 3.86 | ||
| P-4010 (15) | 12 (75.0) | 1.92 | 3.57 | ||
| Placebo | 14 (87.5) | 2.65 | 3.61 | ||
| 7 | P-4010 (300) | 36 | 23 (65.7)a | 1.31 | 3.70 |
| Placebo | 31 (86.1) | 2.05 | 3.06 | ||
a
Swab not available from one animal.