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. 2022 Feb;11(2):224–237. doi: 10.21037/tlcr-22-50

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2022 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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CpG sites with known genomic features in 6 patients. CpG sites with no less than 3× coverage were counted, as shown in this figure. Similar CpG sites (CT similar) corresponding to genomic features with a normal P value >0.05 and a methylation difference <10% were counted between the CTCs and matched tumor tissues. Differential CpG sites (CT diff) corresponding to genomic features with a normal P value <0.05 and an absolute methylation difference >0.1 were counted in the CTCs compared to matched tumor tissues. The DMCs that appeared in 2 of the 6 patients are illustrated in this figure. CTC, circulating tumor cell.