Table 4. Serum cytokines of IPF and healthy volunteers*.
| Parameters | IPF (n=69) | Healthy volunteers (n=30) | P value |
|---|---|---|---|
| IL-1 ra | 82.61 (65.20–110.00) | 57.99 (27.49–79.05) | <0.001 |
| IL-2 | 0.5600 (0.3500–0.9550) | 0.3900 (0.0150–0.6700) | 0.007 |
| IL-6 | 0.6800 (0.4700–1.3150) | 0.3400 (0.1700–0.8175) | 0.001 |
| IL-9 | 37.36 (21.78–38.85) | 46.49 (33.14–49.09) | 0.005 |
| IL-10 | 0.4200 (0.1300–1.0800) | 0.0450 (0.0150–0.3250) | 0.001 |
| IL-12 | 0.4400 (0.2800–0.7200) | 0.1250 (0.0150–0.3275) | <0.001 |
| G-CSF | 13.130 (8.660–21.575) | 6.635 (2.350–11.282) | 0.001 |
| PDGF-BB | 158.38 (64.58–466.49) | 63.07 (53.17–113.27) | <0.001 |
| MIP-1β/CCL4 | 113.29 (51.42–263.53) | 621.71 (264.96–884.63) | <0.001 |
| RANTES/CCL5 | 3,415 (2,865–4,656) | 4,447 (3,332–5,061) | 0.016 |
| VEGF-A | 2.010 (2.010–16.925) | 0.615 (0.615–5.796) | <0.001 |
| IL-1β | 0.4000 (0.2000–0.565) | 0.4000 (0.2775–0.6500) | 0.799 |
| IL-4 | 0.5500 (0.4100–0.8150) | 0.5050 (0.3825–0.850) | 0.417 |
| IL-5 | 0.0300 (0.0150–1.8150) | 0.0300 (0.0300–0.8325) | 0.087 |
| IL-7 | 3.740 (2.980–5.170) | 4.180 (2.280–5.320) | 0.921 |
| IL-8 | 2.840 (2.090–3.870) | 1.925 (1.487–3.327) | 0.053 |
| IL-13 | 0.5300 (0.3650–0.9500) | 0.6300 (0.2700–1.0675) | 0.957 |
| IL-15 | 13.81 (13.81–15.34) | 7.8550 (0.7350–16.095) | 0.096 |
| IL-17 | 3.470 (2.450–4.055) | 3.330 (2.285–4.182) | 0.451 |
| Eotaxin/CCL11 | 34.82 (26.16–47.52) | 34.14 (28.79–46.87) | 0.775 |
| b-FGF | 8.740 (6.815–10.135) | 9.190 (8.107–9.980) | 0.379 |
| GM-CSF | 0.030 (0.2500–0.5500) | 0.1150 (0.010–0.4375) | 0.542 |
| IFNγ | 2.120 (1.535–3.700) | 2.430 (1.202–3.595) | 0.840 |
| IP-10/CXCL10 | 321.71 (246.28–460.07) | 325.29 (235.13–443.72) | 0.982 |
| MCP-1/CCL2 | 9.930 (6.820–14.645) | 9.060 (6.110–12.397) | 0.426 |
| MIP-1α/CCL3 | 0.7500 (0.4700–1.5150) | 0.5900 (0.3650–1.9775) | 0.479 |
| TNF-α | 13.62 10.35–15.59) | 15.04 (10.78–15.72) | 0.428 |
*, serum cytokine levels (pg/mL) of IPF and healthy volunteers were compared with Mann-Whitney U test. IL, interleukin; CCL, CC chemokine ligand; bFGF, basic fibroblast growth factor; G-CSF; granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IP-10, IFN-γ inducible protein; CXCL, CXC chemokine ligand; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; PDGF, platelet-derived growth factor; RANTES, regulated on activation, normal T-cell expressed and secreted; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.