Table 7. Correlation between serum cytokines levels and clinical parameters.
| Parameters* | ρ (Spearman’s rank correlation) | ||||
|---|---|---|---|---|---|
| %FVC | mMRC (<2/≥2) | Neu in BAL | Lymph in BAL | Corticosteroid before AE | |
| IL-1β | 0.021 | 0.096 | 0.004 | −0.121 | 0.098 |
| IL-ra | −0.080 | −0.114 | 0.094 | −0.218 | −0.086 |
| IL-2 | 0.003 | −0.045 | 0.220 | −0.088 | 0.098 |
| IL-4 | 0.155 | −0.035 | 0.130 | −0.021 | −0.030 |
| IL-5 | 0.181 | −0.206 | 0.144 | −0.047 | −0.151 |
| IL-6 | 0.022 | −0.164 | 0.170 | −0.079 | −0.129 |
| IL-7 | 0.043 | 0.012 | 0.214 | 0.078 | −0.028 |
| IL-8 | −0.057 | −0.064 | 0.229 | −0.124 | −0.124 |
| IL-9 | 0.108 | 0.075 | −0.001 | −0.093 | 0.022 |
| IL-10 | 0.060 | −0.198 | 0.070 | −0.045 | −0.121 |
| IL-12 | −0.085 | 0.049 | 0.244† | −0.025 | 0.048 |
| IL-13 | −0.072 | 0.237 | 0.198 | −0.079 | 0.147 |
| IL-15 | 0.083 | 0.087 | 0.149 | 0.372‡ | 0.037 |
| IL-17 | 0.043 | 0.087 | 0.002 | −0.082 | 0.066 |
| Eotaxin/CCL11 | −0.013 | 0.078 | 0.000 | −0.007 | 0.022 |
| b-FGF | 0.046 | 0.035 | 0.070 | −0.034 | 0.014 |
| G-CSF | 0.072 | −0.073 | 0.299† | −0.128 | 0.044 |
| GM-CSF | −0.117 | 0.123 | 0.264† | 0.078 | 0.143 |
| IFNγ | 0.072 | 0.054 | 0.237 | −0.041 | −0.091 |
| IP-10/CXCL10 | 0.145 | −0.381‡ | −0.006 | −0.034 | −0.195 |
| MCP-1/CCL2 | 0.172 | −0.148 | 0.096 | −0.254† | −0.151 |
| MIP-1α/CCL3 | 0.131 | −0.164 | 0.254† | −0.241† | 0.004 |
| PDGF-BB | −0.137 | 0.072 | −0.040 | −0.223 | 0.133 |
| MIP-1β/CCL4 | 0.038 | −0.167 | 0.239† | 0.119 | −0.117 |
| RANTES/CCL5 | −0.029 | −0.130 | 0.089 | −0.087 | −0.050 |
| TNF-α | 0.117 | −0.079 | 0.013 | −0.096 | −0.047 |
| VEGF-A | 0.009 | −0.111 | 0.115 | −0.163 | −0.004 |
†, P<0.05; ‡, P<0.01; *, cytokine levels were used as pg/mL. BAL, bronchoalveolar lavage; b-FGF, basic fibroblast growth factor; CCL, CC chemokine ligand; CI, confidence interval; CXCL, CXC chemokine ligand; G-CSF; granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HR, hazard ratio; HRCT, high-resolution computed tomography; IFN, interferon; IIP, idiopathic interstitial pneumonia; IL, interleukin; IP-10, IFN-γ inducible protein; Lymph, lymphocytes; MCP, monocyte chemotactic protein; MIP, macrophage inflammatory protein; mMRC, modified Medical Research Council score for shortness of breathe; Neu, neutrophils; %FVC, percent predicted value of forced vital capacity; PDGF, platelet-derived growth factor; RANTES, regulated on activation, normal T-cell expressed and secreted; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.