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. 2022 Feb;14(2):474–493. doi: 10.21037/jtd-22-126

Figure 4.

Figure 4

The effects of RDN on macrophage polarization and the A549 cell AhR-Src-STAT3-IL-10 pathway in the coculture system. (A) Western blot assay of CD86, CD163, and β-actin levels in THP-1 cells. (B,C) Western blot assay of AhR, p-Src, Src, p-STAT3, STAT3, IL-10, and β-actin levels in A549 cells and sh-AhR A549 cells. The values represent the mean ± SD of 3 independent experiments, and the differences between the mean values were assessed by the Student’s t-test. *, P<0.05, **, P<0.01 vs. the control group; #, P<0.05, ##, P<0.01 vs. the IFN-γ, LPS, IL-4, and IL-13 groups. RDN, Reduning; AhR, Aryl hydrocarbon receptor; p-Src, Phosphorylation Src tyrosine kinase; Src, Src tyrosine kinase; p-STAT3, Phosphorylation signal transducer and activator of transcription 3; STAT3, signal transducer and activator of transcription 3; IL-10, interleukin 10; LPS, lipopolysaccharide; IL-4, interleukin 4; IL-13, interleukin 13; IFN-γ, interferon γ; CD86, cluster of differentiation 86; CD163, cluster of differentiation 163.