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. 2022 Feb;14(2):474–493. doi: 10.21037/jtd-22-126

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2022 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Effects of RDN on survival rate, lung histopathological changes and X-ray in severe pneumonia rats. (A) Survival rate and bacterial load in rats. The data are shown as the means ± SD. **, P<0.01 indicates significant differences compared to the control group; ^#, P<0.05 vs. the model group; ^##, P<0.01 vs. the model group; ^Δ, P<0.05 vs. the CMZ group; ^ΔΔ, P<0.01 vs. the CMZ group. (B) Changes in the chest X-rays of the rats with severe pneumonia in each group. (C) The effects of RDN and CMZ on histopathological changes in lung tissues in rats with severe pneumonia [hematoxylin-eosin staining (HE), ×200]. RDN, Reduning; CMZ, Cefmetazole.