Figure 1.

Human periodontitis-causing bacteria efficiently colonize in the mouse model. (A) Schematic illustration of experimental design. LIP, ligature-induced periodontitis. SP, subgingival plaques from patients with periodontitis. CMC, carboxymethylcellulose, and SAC, sacrifice. (B) The Venn diagrams showing the overlapped and different bacteria species between mouse silk ligature and human subgingival plaque (left), and between human subgingival plaque and mouse saliva (right). (C) Taxonomic composition of bacterial community at species level in mouse silk ligature and human subgingival plaque. (D) Taxonomic composition of bacterial community at species level in mouse saliva and human subgingival plaque. (E) β-diversity of SP and saliva, silk ligature bacteria at species level in LIP + SP group, assessed by principal coordinate analysis (PCoA) based on bray–curtis distance. (n = 5:5).