Table 3.

Key defining mutations for VOCs (https://covariants.org/).

		B.1.1.7 (Alpha)	B.1.351 (Beta)	P.1 (Gamma)	B.1.617.2 (Delta)	B.1.1.529 (Omicron)
Mutations on structural proteins	Spike	H69del, V70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H	D80A, D215G, L241del, L242del, A243del, K417N, E484K, N501Y, D614G, A701V	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F,	T19R, E156del, F157del, R158G, L452R, T478K, D614G, P681R, D950N	A67V, H69del, V70del, T95I, G142del, V143del, Y144del, Y145D, N211del, L212I, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
	Nucleocapsid	D3L, R203K, G204R, S235F	T205I	P80R, R203K, G204R	D63G, R203M, D377Y	P13L, E31del, R32del, S33del, R203K, G204R
	Envelope		P71L			T9I
	Membrane				I82T	D3G, Q19E, A63T
Mutations on non-structural proteins	ORF1a	T1001I, A1708D, I2230T, S3675del, G3676del, F3677del	T265I, K1655N, K3353R, S3675del, G3676del, F3677del	S1188L, K1795Q, S3675del, G3676del, F3677del		K856R, S2083del, L2084I, A2710T, T3255I, P3395H, L3674del, S3675del, G3676del, I3758V
	ORF1b	P314L	P314L	P314L, E1264D	P314L, G662S, P1000L	P314L, I1566V
	ORF3a		Q57H	S253P	S26L
	ORF7a				V82A, T120I
	ORF8	Q27*, R52I, Y73C		E92K	D119del, F120del
	ORF9b				T60A	P10S, E27del, N28del, A29del

^*Stop codon.