TABLE 1.
Effect of treatment with CAM alone on growth of the 13762NF tumor in F-344 rats
| CAM treatment (mg/kg)a | Days of treatment | Survival rate (% surviving) on day 50b |
|---|---|---|
| Expt 1 | ||
| 32 | 8–28 | 0/9 (0) |
| 8 | 8–28 | 0/9 (0) |
| 2 | 8–28 | 1/9 (11) |
| 0.5 | 8–28 | 2/9 (22) |
| None | 0/10 (0) | |
| Expt 2 | ||
| 2 | −5–∼−1 and +1–∼+16 | 5/12 (42)c |
| 2 | +1–∼+21 | 4/12 (33) |
| 2 | +8–∼+28 | 2/12 (17) |
| None | 0/12 (0) |
a
Tumor cells (2 × 106) were administered s.c. on day 0. CAM was given p.o. according to the schedule.
b
Animals without a tumor or animals with a regressing tumor were recorded on day 50 after tumor inoculation.
c
P < 0.05 versus the untreated group.