TABLE 2.
Combined effect of CY and CAM and CBDCA and CAM on growth of the 13762NF tumor in F-344 rats
| Treatmenta | Day(s) of treatment | Survival rate (% surviving) on day 50b |
|---|---|---|
| Expt 1 | ||
| CY (60 mg/kg) | 8 | 3/11 (27) |
| CAM (2 mg/kg) | 9–29 | 2/12 (17) |
| CY + CAM | 6/12 (50)c | |
| None | 0/12 (0) | |
| Expt 2 | ||
| CBDCA (50 mg/kg) | 8 | 0/12 (100) |
| CAM (2 mg/kg) | 9–29 | 0/12 (100) |
| CBDCA + CAM | 6/12 (50)c | |
| None | 0/12 (100) |
a
Tumor cells (2 × 106) were administered s.c. on day 0. CY at 60 mg/kg i.v. or CBDCA at 50 mg/kg i.p. was administered on day 8, and CAM at 2 mg/kg p.o. was administered on days 9 to 29.
b
Animals without tumor or animals with a regressing tumor were recorded on day 50 after tumor inoculation.
c
P < 0.025 versus the untreated group.