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. 2022 Feb 22;12:808480. doi: 10.3389/fphar.2021.808480

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Copyright © 2022 Li, Liu, Pi, Zhang, Yu, Xu, Sun and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fisetin attenuates DOX-induced myocardial dysfunction in rats. (A). Representative echocardiogram images of each group. Results of (B) LVEF, (C) LVFS, (D) LVIDs, and (E) LVIDd in four group experimental rats (n = 6 per group). The results showed the effect of fisetin on attenuating DOX-induced LV dysfunction. The values are presented as mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; NS, no significance; LV, left ventricular; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVIDs, LV end-systolic internal dimension; LVIDd, LV end-diastolic internal dimension.