TABLE 1.
MLC of metronidazole for metronidazole-sensitive and metronidazole-resistant G. duodenalis, T. vaginalis, and E. histolytica
| Species and strain | MZ concn (μM)a | MLC (μM)b | Reference |
|---|---|---|---|
| G. duodenalis | |||
| BRIS/83/HEPU/106 | 100 | 5 | |
| BRIS/91/HEPU/1279 | 50 | 25 | |
| BRIS/83/HEPU/106-2ID10c | 5.8 | >500 | 1 |
| WB1B-M3c | 42 | >500 | 23 |
| T. vaginalis | |||
| BRIS/92/STDL/F1623 | 50 | 4 | |
| BRIS/92/STDL/F1623-M1c | 400 | >500 | 4 |
| E. histolytica HTH-56:MUTM | 50 | 20 |
a
The metronidazole (MZ) concentration was maintained in the medium for metronidazole-resistant lines. Metronidazole at 1 μM is equal to 0.17 μg/ml.
b
The MLC is the lowest concentration of metronidazole at which no viable organisms were observed following exposure to drug for 3 days and growth for a further 4 days in fresh drug-free medium.
c
Metronidazole-resistant lines.