TABLE 2.
Antiprotozoal activity of nitroimidazole derivatives against metronidazole-sensitive and metronidazole-resistant strains of G. duodenalis, T. vaginalis, and E. histolyticaa
| Compound | MLC (μM)b
|
||||||
|---|---|---|---|---|---|---|---|
|
G. duodenalis
|
T. vaginalis
|
E. histo-lytica MUTM (MZs) | |||||
| 106 (MZs) | 1279 (MZs) | 2ID10 (MZr) | WB1B-M3 (MZr) | F1623 (MZs) | F1623-M1 (MZr) | ||
| MZ | 100 | 50 | >500 | >500 | 50 | >500 | 50 |
| 1 | 100 | 50 | 100 | 100 | 10 | ND | 50 |
| 2 | 50 | 50 | 100 | 100 | <1 | ND | >50 |
| 3 | >100 | >50 | >500 | ND | >50 | >500 | >100 |
| 4 | <5 | 5 | >50 | 50 | <1 | >500 | 50 |
| 5 | 50 | 5 | 100 | >100 | 10 | ND | >50 |
| 6 | <5 | 5 | >50 | >10 | <1 | 500 | >50 |
| 7 | >10 | 10 | >50 | >50 | 5 | 500 | 50 |
| 8 | 50 | 50 | 500 | >500 | 50 | ND | >50 |
| 9 | 50 | 50 | >100 | >50 | 5 | ND | >50 |
| 10 | <5 | 10 | 10 | >50 | 5 | >500 | 50 |
| 11 | ND | 5 | >100 | 500 | 5 | >500 | >50 |
| 12 | >5 | 10 | >50 | 50 | 5 | ND | 50 |
| 13 | 1 | 1 | 5 | 10 | <1 | >100 | >5 |
a
Abbreviations: MZ, metronidazole; MZr, metronidazole resistant; MZs, metronidazole sensitive; ND, not done.
b
See Table 1 for complete strain designations.