. 2021 Nov 15;13(3):489–500. doi: 10.1111/jdi.13698

Table 6.

Subgroup analyses of change in gastrointestinal symptom rating scale total score and glycated hemoglobin among full analysis set group

		Change from observation 1 to observation 2	P
Age <65 years	GSRS total score (n = 17)	−0.52 ± 0.46	<0.001
Age <65 years	HbA1c (%) (n = 17)	0.0 ± 0.4	0.73
Age ≥65 years	GSRS total score (n = 23)	−0.37 ± 0.51	0.002
Age ≥65 years	HbA1c (%) (n = 23)	0.0 ± 0.4	0.88
Men	GSRS total score (n = 26)	−0.42 ± 0.51	<0.001
Men	HbA1c (%) (n = 26)	0.1 ± 0.4	0.28
Women	GSRS total score (n = 14)	−0.45 ± 0.46	0.003
Women	HbA1c (%) (n = 14)	−1.7 ± 2.7	0.033
BMI <25 kg/m²	GSRS total score (n = 25)	−0.36 ± 0.51	0.002
BMI <25 kg/m²	HbA1c (%) (n = 25)	0.1 ± 0.4	0.29
BMI ≥25 kg/m²	GSRS total score (n = 13)	−0.52 ± 0.48	0.002
BMI ≥25 kg/m²	HbA1c (%) (n = 13)	−0.1 ± 0.4	0.17
Constipation symptoms (−)	GSRS total score (n = 18)	−0.39 ± 0.34	<0.001
Constipation symptoms (−)	HbA1c (%) (n = 18)	0.0 ± 0.4	0.96
Constipation symptoms (+)	GSRS total score (n = 22)	−0.47 ± 0.59	0.001
Constipation symptoms (+)	HbA1c (%) (n = 22)	0.0 ± 0.4	0.191
Diarrhea symptoms (−)	GSRS total score (n = 29)	−0.39 ± 0.47	<0.001
Diarrhea symptoms (−)	HbA1c (%) (n = 29)	0.0 ± 0.4	0.77
Diarrhea symptoms (+)	GSRS total score (n = 11)	−0.56 ± 0.53	0.006
Diarrhea symptoms (+)	HbA1c (%) (n = 11)	0.0 ± 0.5	0.85

Student's t‐tests were carried out to assess statistical significance. BMI, body mass index; GSRS, gastrointestinal symptom rating scale; HbA1c, glycated hemoglobin.