Table 1.
Thirty representative DEGs up-regulated in the GPR15L-transfected NHEKs.
| Symbol | Fold* | logCPM | LR | P-Value | FDR | Protein | Category** |
|---|---|---|---|---|---|---|---|
| C10orf99 | 326.97 | 6.66 | 588.23 | 6.09E-130 | 9.83E-126 | chromosome 10 open reading frame 99 | – |
| CTGF | 32.95 | 6.05 | 103.23 | 2.99E-24 | 6.03E-21 | connective tissue growth factor | KC differentiation |
| DUSP1 | 28.95 | 4.95 | 66.37 | 3.74E-16 | 1.89E-13 | dual specificity phosphatase 1 | Inflammation |
| SDF4 | 20.12 | 4.77 | 49.91 | 1.61E-12 | 3.42E-10 | stromal cell derived factor 4 | KC differentiation |
| INA | 15.79 | 2.03 | 34.66 | 3.92E-09 | 3.42E-07 | internexin neuronal intermediate filament protein alpha | Others |
| MAFF | 14.77 | 4.32 | 99.02 | 2.50E-23 | 4.03E-20 | MAF bZIP transcription factor F | Others |
| MARC1 | 11.77 | 2.00 | 58.63 | 1.91E-14 | 6.28E-12 | mitochondrial amidoxime reducing component 1 | Mitochondria |
| LINC00702 | 8.74 | 2.30 | 25.52 | 4.38E-07 | 2.18E-05 | (long intergenic non-protein coding RNA 702) | Others |
| CSF1 | 7.39 | 2.51 | 62.13 | 3.21E-15 | 1.20E-12 | colony stimulating factor 1 | Inflammation |
| PREP | 6.56 | 6.18 | 69.31 | 8.40E-17 | 4.52E-14 | prolyl endopeptidase | Mitochondria |
| COQ2 | 6.10 | 4.35 | 20.57 | 5.74E-06 | 1.83E-04 | coenzyme Q2, polyprenyltransferase | Mitochondria |
| BTG1 | 5.95 | 5.18 | 64.32 | 1.06E-15 | 4.87E-13 | BTG anti-proliferation factor 1 | Others |
| IL24 | 4.61 | 5.59 | 126.04 | 3.02E-29 | 1.62E-25 | interleukin 24 | Inflammation |
| MMP3 | 4.50 | 2.67 | 56.37 | 6.02E-14 | 1.77E-11 | matrix metallopeptidase 3 | KC differentiation |
| CAPN8 | 4.34 | 2.48 | 49.60 | 1.89E-12 | 3.96E-10 | calpain 8 | Inflammation |
| TRAF4 | 4.24 | 4.90 | 87.18 | 9.90E-21 | 8.87E-18 | TNF receptor associated factor 4 | Inflammation |
| SOCS3 | 3.18 | 2.18 | 18.18 | 2.01E-05 | 5.26E-04 | suppressor of cytokine signaling 3 | Inflammation |
| IL6 | 3.05 | 2.08 | 27.16 | 1.87E-07 | 1.02E-05 | interleukin 6 | Inflammation |
| NGF | 3.04 | 2.02 | 12.49 | 4.10E-04 | 6.04E-03 | nerve growth factor | Others |
| MAP3K11 | 3.00 | 3.59 | 12.42 | 4.24E-04 | 6.17E-03 | mitogen-activated protein kinase kinase kinase 11 | Inflammation |
| CSF2 | 2.84 | 2.22 | 21.38 | 3.77E-06 | 1.30E-04 | colony stimulating factor 2 | Inflammation |
| IL20 | 2.81 | 2.47 | 26.15 | 3.16E-07 | 1.63E-05 | interleukin 20 | Inflammation |
| TXNRD3 | 2.67 | 3.24 | 32.90 | 9.70E-09 | 7.83E-07 | thioredoxin reductase 3 | Inflammation |
| RELB | 2.60 | 2.45 | 18.18 | 2.01E-05 | 5.26E-04 | RELB proto-oncogene, NF-kB subunit | Inflammation |
| IL7R | 2.50 | 3.54 | 20.23 | 6.87E-06 | 2.12E-04 | interleukin 7 receptor | Inflammation |
| MAP2K5 | 2.26 | 3.81 | 18.06 | 2.14E-05 | 5.49E-04 | mitogen-activated protein kinase kinase 5 | Inflammation |
| PTGER4 | 2.24 | 3.84 | 12.79 | 3.49E-04 | 5.32E-03 | prostaglandin E receptor 4 | Inflammation |
| CIITA | 2.22 | 2.13 | 11.18 | 8.26E-04 | 1.05E-02 | class II major histocompatibility complex transactivator | Inflammation |
| SEMA3E | 2.15 | 3.03 | 13.26 | 2.70E-04 | 4.40E-03 | semaphorin 3E | Inflammation |
| JUN | 2.14 | 7.61 | 28.73 | 8.34E-08 | 4.98E-06 | proto-oncogene c-Jun | Inflammation |
*Shading with orange ≥ 10, light orange ≥ 3. **Colored according to the category.