Table 2.
Clinical, molecular and immunophenotypic features of pleomorphic adenoma
| Case No. | Age | Sex | Location | PLAG1 FISH (% of cells translocated in 60-102 cells evaluated) | PLAG1 IHC | HMGA2 IHC |
|---|---|---|---|---|---|---|
| 1 | 12 | F | Parotid | + (60/64, 93.7%) | + | + |
| 2 | 23 | F | Parotid | + (56/64, 87.5%) | - | - |
| 3 | 43 | F | Parotid | + (55/60, 91.7%) | - | - |
| 4 | 66 | F | Parotid | + (43/60, 71.7%) | - | + |
| 5 | 66 | M | Parotid | - (2/62, 3.2%)* | - | + |
| 6 | 48 | F | Parotid | - (0/62, 0%) | - | + |
| 7 | 30 | M | Submandibular | - (0/102, 0%) | + | - |
| 8 | 64 | F | Submandibular | - (0/61, 0%) | - | + |
| 9 | 33 | M | Parotid | Hybridization failed x2 | - | - |
| 10 | 45 | F | Parotid | Hybridization failed x2 | - | - |
| 11 | 66 | F | Parotid | Hybridization failed x2 | - | + |
| 12 | 53 | F | Submandibular | Hybridization failed x2 | - | + |
| 13 | 42 | M | Parotid | Hybridization failed x2 | - | + |
| 14 | 60 | F | Parotid | Hybridization failed x2 | - | - |
| 15 | 65 | F | Parotid | Hybridization failed x2 | - | - |
| 16 | 56 | M | Parotid | Hybridization failed x2 | - | + |
| 17 | 42 | F | Parotid | Hybridization failed x2 | - | - |
| 18 | 39 | M | Submandibular | Hybridization failed x2 | - | - |
| 19 | 38 | F | Parotid | Hybridization failed x2 | - | + |
| 20 | 40 | F | Parotid | Hybridization failed x2 | - | - |
| 21 | 46 | F | Submandibular | Hybridization failed x2 | - | - |
| 22 | 17 | F | Upper lip | Hybridization failed x2 | - | - |
| 23 | 42 | F | Parotid | Hybridization failed x2 | - | - |
| 24 | 13 | F | Palate | Hybridization failed x2 | - | + |
| 25 | 28 | F | Submandibular | Hybridization failed x2 | - | + |
*
- The cutoff for positivity is translocation in 9.93% of examined cells, IHC - Immunohistochemistry, (+) - positive, (-) - negative.