TABLE 1.
Spleen weights of mice after treatment with moxifloxacin, INH, or moxifloxacin plus INH following inoculation of M. tuberculosis
| Treatment (daily dose) | Mean spleen weight (mg) of mice after treatment for:a
|
|
|---|---|---|
| 4 weeks | 8 weeks | |
| Control, water | 214 ± 26 | 183 ± 55 |
| INH (25 mg/kg) | 68 ± 14b | 93 ± 10b |
| Moxifloxacin (100 mg/kg) | 84 ± 24b | 71 ± 10bc |
| Moxifloxacin (100 mg/kg) + INH (25 mg/kg) | 71 ± 14b | 70 ± 9bc |
a
Mice (n = 8 for each treatment at each time) were intravenously inoculated with 5.9 × 105 CFU of M. tuberculosis before treatment. Values shown are the means ± standard deviations.
b
Significantly lower than the weight in the control group (P < 0.001).
c
Significantly lower than the weight in the INH group (P < 0.01).