TABLE 2.
CFU counts in organ homogenates after treatment with moxifloxacin, INH, or moxifloxacin plus INH following inoculation of M. tuberculosis
| Treatment (daily dose) | CFU counta in homogenates of:
|
|
|---|---|---|
| Lung | Spleen | |
| 4 weeks | ||
| Control, water | 5.64 ± 0.12 | 4.88 ± 0.18 |
| INH (25 mg/kg) | 0.38 ± 0.19b | 1.23 ± 0.18b |
| Moxifloxacin (100 mg/kg) | 0.63 ± 0.22b | 1.51 ± 0.24b |
| Moxifloxacin (100 mg/kg) + INH (25 mg/kg) | 0.17 ± 0.11b | 0.66 ± 0.20bc |
| 8 weeks | ||
| Control, water | 6.45 ± 0.48 | 4.57 ± 0.31 |
| INH (25 mg/kg) | 0.10 ± 0.26b | 0.49 ± 0.47b |
| Moxifloxacin (100 mg/kg) | 0 ± 0bd | 0.74 ± 0.79b |
| Moxifloxacin (100 mg/kg) + INH (25 mg/kg) | 0 ± 0bd | 0 ± 0bd |
a
Mice (n = 8 for each treatment at each time) were intravenously inoculated with 5.9 × 105 CFU of M. tuberculosis before treatment. The values given are log10 CFU counts (means ± standard deviations).
b
Significantly lower than the counts in the control group (P < 0.001).
c
Significantly lower than the counts in the other treatment groups (P < 0.02).
d
Zero denotes absence of colonies in any organ homogenates (the lower limit of detection is <0.1).