Table 3.
Hematologic values and Hb profiles of 21 at-risk couples who had affected fetuses with Hb E-β0-thalassemia and heterozygous α0-thalassemia (SEA), including results of α0-thalassemia analysis of the couples
| Group | Number of couples (%) | Hb analysis | α0-thal gene (SEA) | Rbc (x1012/L) | Hb (g/dL) | HCT (%) | MCV (fL) | MCH (pg) | RDW (%) | Hb A2/E (%) | Hb F (%) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 10 (47.6) | Husband/Wife | A2A; Hb A2>3.5% | Pos | 5.4±1.0 | 11.6±1.8 | 35.7±5.1 | 66.1±4.9 | 21.1±1.6 | 15.4±2.1 | 5.8±0.8 | 1.3±0.5 |
| Husband/Wife | EA; Hb E>25% | Neg | 5.3±0.6 | 12.8±2.3 | 38.8±6.5 | 73.1±8.0 | 24.4±3.3 | 14.1±2.8 | 28.4±1.1 | 1.2±0.7 | ||
| 2 | 3 (14.3) | Husband/Wife | A2A; Hb A2>3.5% | Pos | 5.8±0.7 | 11.2±2.7 | 35.1±7.2 | 59.6±5.5 | 19.0±24 | 18.2±2.0 | 5.7±0.6 | 0.5±0.4 |
| Husband/Wife | EA; Hb E≤25% | Pos | 4.9±0.1 | 10.5±0.4 | 31.5±1.1 | 64.8±3.7 | 21.5±0.7 | 14.6±0.7 | 21.7±0.7 | 0.5±0.3 | ||
| 3 | 3 (14.3) | Husband/Wife | A2A; Hb A2>3.5% | Neg | 6.3±0.7 | 12.2±1.4 | 40.0±3.5 | 63.9±3.1 | 19.5±1.0 | 13.9±0.1 | 5.8±0.5 | 1.7±0.9 |
| Husband/Wife | EA; Hb E≤25% | Pos | 5.8±0.7 | 12.1±1.5 | 38.3±5.0 | 71.3±5.8 | 21.0±0.1 | 16.0±2.5 | 19.7±0.8 | 1.2±0.8 | ||
| 4 | 1 (4.8) | Husband | EE | Neg | 6.8 | 13.4 | 42.5 | 62.8 | 19.8 | 15.3 | 98.8 | 1.2 |
| Wife | A2A; Hb A2>3.5% | Pos | 5.3 | 11.0 | 34.9 | 65.9 | 20.8 | 16.9 | 5.7 | 0 | ||
| 5 | 1 (4.8) | Husband | A2A; Hb A2>3.5% | Neg | 4.6 | 10.9 | 30.4 | 66.5 | 23.9 | 13.8 | 5.2 | 0.5 |
| Wife | EE | Pos | 5.8 | 13.6 | 40.1 | 69.0 | 23.3 | 20.1 | 98.5 | 1.5 | ||
| 6 | 1 (4.8) | Husband | EE | na | 5.6 | 11.8 | 34.8 | 62.0 | 21.0 | 15.8 | 96.5 | 3.5 |
| Wife | A2A; Hb A2>3.5% | na | 5.3 | 11.4 | 36 | 67.0 | 21.3 | 14.8 | 5.2 | 1.1 | ||
| 7 | 1 (4.8) | Husband | EE | Pos | 6.3 | 13.2 | 37.9 | 60.1 | 20.9 | 18.6 | 90.2 | 1.9 |
| Wife | EF | Pos | 4.9 | 8.2 | 23.8 | 48.8 | 16.7 | 21.9 | 66.6 | 33.4 | ||
| 8 | 1 (4.8) | Husband | EF | Neg | 5.4 | 10.2 | 33.4 | 61.3 | 18.7 | 27.1 | 63.2 | 36.8 |
| Wife | EA; Hb E≤25% | Pos | 5.2 | 10.7 | 34 | 65.7 | 20.7 | 16.4 | 19.2 | 0.7 | ||
Values are presented as mean ± standard deviation or as raw data where appropriated. Pos: Positive; Neg: Negative; na: not available.