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. 2022 Feb 15;14(2):1172–1187.

Table 1.

A summary of cardiac stromal cell markers identified through the years, and sorted as classical or derived from novel omics approaches

Classical Markers New Omics Markers


Cell surface and Intracellular Extracellular Transcriptional Cell surface, Extracellular & Transcriptional
Unactivated Fibroblasts PDGFRα, DDR2, CD29, CD49e, CD51, CD73, CD90, CD105, Sca1, Vimentin, Filamin A Collagens, TNC GATA4, GATA6, Nkx-2.5, Hand2, Tbx18, Tbx20, Tcf-21, WT1 DCN, ELN, GSN
Activated Fibroblasts ↑CD105, CD90, ↓PDGFRα, ↑Vimentin, ↑DDR2, α-SMA POSTN, Collagens ↓Tcf21, ↑Tbx18, ↑Wt1 Wisp1, Ckap4
Myofibroblasts ↑CD105, ↓PDGFRα, ↓DDR2, ↑α-SMA ↑↑Collagens ↓Tcf21 MYH11, FAP
Matrifibrocytes CHAD, COMP
Pericytes PDGFRα, PDGFRβ, NG2, CD146, CD73, CD90, CD105, CD271, SM-MHC, α-SMA NCAM2, CD38, CSPG4, ABCC9, KCNJ8
Telocytes CD34, CD117, PDGFRα, PDGFRβ, Vimentin
Mesenchymal & Progenitor cells CD51, CD105, CD73, CD90, Sca1, PDGFRα, Filamin A, Vimentin Collagens Islet-1, Tbx5, GATA4, Nkx-2.5, MEF2C, Tcf21, NANOG, OCT-4 CD38, ICAM2, Caecam1, CD36, CD93, CD322, KITL, JAG2, VEGF-C