Table 1.
A summary of cardiac stromal cell markers identified through the years, and sorted as classical or derived from novel omics approaches
| Classical Markers | New Omics Markers | |||
|---|---|---|---|---|
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| Cell surface and Intracellular | Extracellular | Transcriptional | Cell surface, Extracellular & Transcriptional | |
| Unactivated Fibroblasts | PDGFRα, DDR2, CD29, CD49e, CD51, CD73, CD90, CD105, Sca1, Vimentin, Filamin A | Collagens, TNC | GATA4, GATA6, Nkx-2.5, Hand2, Tbx18, Tbx20, Tcf-21, WT1 | DCN, ELN, GSN |
| Activated Fibroblasts | ↑CD105, CD90, ↓PDGFRα, ↑Vimentin, ↑DDR2, α-SMA | POSTN, Collagens | ↓Tcf21, ↑Tbx18, ↑Wt1 | Wisp1, Ckap4 |
| Myofibroblasts | ↑CD105, ↓PDGFRα, ↓DDR2, ↑α-SMA | ↑↑Collagens | ↓Tcf21 | MYH11, FAP |
| Matrifibrocytes | CHAD, COMP | |||
| Pericytes | PDGFRα, PDGFRβ, NG2, CD146, CD73, CD90, CD105, CD271, SM-MHC, α-SMA | NCAM2, CD38, CSPG4, ABCC9, KCNJ8 | ||
| Telocytes | CD34, CD117, PDGFRα, PDGFRβ, Vimentin | |||
| Mesenchymal & Progenitor cells | CD51, CD105, CD73, CD90, Sca1, PDGFRα, Filamin A, Vimentin | Collagens | Islet-1, Tbx5, GATA4, Nkx-2.5, MEF2C, Tcf21, NANOG, OCT-4 | CD38, ICAM2, Caecam1, CD36, CD93, CD322, KITL, JAG2, VEGF-C |