Table 2.
Summary of different studies on the outcomes of metabolic surgery in T2DM patients
| Study | Study description | Intervention methods | Follow up period | Key findings |
|---|---|---|---|---|
| Mingrone et al., 2021 [68] | An Italian, open label, RCT | RYGB, BPD vs Medical | 10 years | T2DM remission ↑ in both surgical methods vs medical management |
| N=60 T2DM patients with BMI 35 kg/m2 and above | Allocation ratio (1:1:1) | 58.8% had a relapse during follow up period but they maintained their euglycemic status. The relapse rate was higher among RYGB than the BPD group (52.6% vs 66.7%) | ||
| ↓diabetes related complications | ||||
| Adverse events were higher among the BPD group | ||||
| McGlone et al., 2020 [9] | T2DM patients who require insulin | RYGB, AGB and sleeve gastrectomy vs Basic medical treatment (BMT) | 5 years | ↑insulin cessations among surgical group |
| A retrospective study based on secondary data | ↓overeall health cost | |||
| Young L et al., 2019 [69] | T2DM patients with impaired renal parameters | RYGB, Sleeve Gastrectomy | 10 years | ↑T2DM remissions and glycemic control, ↓BMI and ↓albuminuria |
| N=101 | ||||
| Schauer et al., 2017 [70] | Patients with a BMI between 27 to 43 kg/m2 | RYGB, Sleeve Gastrectomy | 5 years | ↑Weigh loss, ↓insulin use, Imporved lipid profile and quality of life among surgical group |
| N=150 | ||||
| Cummings et al., 2016 [71] | Adults aged 25-65 years | RYGB vs Lifestyle and Medical intervention | 1 year | ↑T2DM remissions and ↓weight of the patients in RYGB groups |
| BMI - 30-45 | No life threatening complications occurred in both group | |||
| N=43 | ||||
| Schauer et al., 2014 [72] | T2DM patients with poor glycemic control | RYGB, Sleeve gastrectomy vs Intensive Medical treatment | 3 years | ↑T2DM remissions, ↓Oral hypoglycemic drugs, ↑Quality of life vs Medical treatment |
| N=150 | ||||
| Arterburn et al., 2013 [73] | Multicentric and retrospective cohort study from USA | RYGB, Sleeve gastrectomy and AGB | 10 years | ↑T2DM remissions in first 5 years of follow up. Nearly one third of relapse for the patients who got initial remission |
| N=4434 | ||||
| Uncontrolled T2DM patients and/or controlled with oral hypoglycemic agents | ||||
| Iaconelli A et al., 2011 [74] | Unblinded case-controlled trials | BPD vs medical treatment | 10 years | ↑T2DM remissions observed in all patients of BPD group after one year follow up |
| Newly diagnosed T2DM with BMI 35 and above | ↓microvascular complications BPD group | |||
| N=110 |