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. 2022 Feb 15;14(2):942–954.

Figure 4.

Figure 4

Effect of blocking with anti-TIGIT mAbs on HBV-specific CTL responses in vitro. In the presence or absence of mAb blocking antibodies, the HBV peptide pool was added to stimulate PBMCs from patients with chronic HBV infection in vitro. Representative flow cytometry flow plots gated on CD8+T cells, showing (A) IFN-γ and (B) IL-2 responses for medium, HBV peptide pool stimulation with IgG, HBV peptide pool stimulation with anti-TIGIT mAb from a chronic HBV-infected individual. Compiled data showing variation in the percentage of (C) IFN-γ+ and (D) IL-2+ CD8+T cells in response to medium, HBV peptide pool stimulation with IgG, and HBV peptide pool stimulation with anti-TIGIT mAb (n=10). P values were calculated with repeated-measures one-way ANOVA test, followed by Tukey’s multiple comparisons test.